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Dehydrocrenatidine
Catalog No. T19934Cas No. 65236-62-6
Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,650 | 10-14 weeks | |
| 50 mg | $3,450 | 10-14 weeks | |
| 100 mg | $5,240 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis. |
| In vitro | In DU145 and MDA-MB-468 cells, Dehydrocrenatidine inhibits cell survival and induces cell apoptosis in a JAK-STAT3-dependent manner. Dehydrocrenatidine reduces the STAT3 phosphorylation stimulated by IL-6, IFN-α, and IFN-γ[1]. Dehydrocrenatidine reduces tetrodotoxin-resistant and sensitive voltage-gated sodium channel currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. |
| In vivo | Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[2]. |
| Alias | TOP 3, TOP-3, O-Methylpicrasidine I, TOP3, Kumujian G |
| Molecular Weight | 254.28 |
| Formula | C15H14N2O2 |
| Cas No. | 65236-62-6 |
| Storage | store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | DMSO: Soluble |
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