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Dehydrocrenatidine
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Catalog No. T19934Cas No. 65236-62-6
Alias TOP-3, TOP3, TOP 3, O-Methylpicrasidine I, Kumujian G
Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.
Dehydrocrenatidine
😃Good
Catalog No. T19934Alias TOP-3, TOP3, TOP 3, O-Methylpicrasidine I, Kumujian GCas No. 65236-62-6
Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,650 | 10-14 weeks | |
| 50 mg | $3,450 | 10-14 weeks | |
| 100 mg | $5,240 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis. |
| In vitro | In DU145 and MDA-MB-468 cells, Dehydrocrenatidine inhibits cell survival and induces cell apoptosis in a JAK-STAT3-dependent manner. Dehydrocrenatidine reduces the STAT3 phosphorylation stimulated by IL-6, IFN-α, and IFN-γ[1]. Dehydrocrenatidine reduces tetrodotoxin-resistant and sensitive voltage-gated sodium channel currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. |
| In vivo | Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[2]. |
| Alias | TOP-3, TOP3, TOP 3, O-Methylpicrasidine I, Kumujian G |
| Molecular Weight | 254.28 |
| Formula | C15H14N2O2 |
| Cas No. | 65236-62-6 |
| Smiles | O(C)C1=C2C=3C(NC2=C(C=C)N=C1)=C(OC)C=CC3 |
| Relative Density. | 1.251 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: Soluble |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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