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DHODH-IN-8
🥰Excellent
Catalog No. T11030Cas No. 1148126-03-7
DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.
DHODH-IN-8
🥰Excellent
Purity: 99.57%
Catalog No. T11030Cas No. 1148126-03-7
DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 111 € | In Stock | |
| 2 mg | 166 € | In Stock | |
| 5 mg | 254 € | In Stock | |
| 10 mg | 374 € | In Stock | |
| 25 mg | 562 € | In Stock | |
| 50 mg | 786 € | In Stock | |
| 100 mg | 1.073 € | In Stock | |
| 500 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | 248 € | In Stock |
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Purity:99.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. |
| Targets&IC50 | DHODH (human):(ki)0.016 μM , DHODH (human):0.13 μM , DHODH (P. falciparum):47.4 μM , DHODH (P. falciparum):5.6 μM |
| In vitro | Dihydroorotic acid dehydrogenase (DHODH) is an attractive chemotherapeutic target among various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and is used to treat human diseases. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by using the FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. Human DHODH (HsDHODH)a and Plasmodium falciparum DHODH (PfDHODH) are both DHODHs using respiratory quinones as terminal electron acceptors[1]. |
| Molecular Weight | 312.75 |
| Formula | C17H13ClN2O2 |
| Cas No. | 1148126-03-7 |
| Smiles | ClC1=C(C2=CC=C(NC(/C(=C(/C)\O)/C#N)=O)C=C2)C=CC=C1 |
| Relative Density. | 1.340 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (175.86 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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