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Dipraglurant
Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model.
Catalog No. T15134Cas No. 872363-17-2
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Purity:98.7%
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Dipraglurant
Catalog No. T15134Alias ADX48621Cas No. 872363-17-2
Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $239 | In Stock | |
| 10 mg | $347 | In Stock | |
| 25 mg | $762 | In Stock | |
| 50 mg | $1,120 | In Stock | |
| 100 mg | $1,490 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $289 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model. |
| Targets&IC50 | mGluR5:21 nM |
| In vitro | The novel mGlu receptor negative allosteric modulator (NAM) bifunctional agent Dipraglurant(1-10 μM; 15 minutes) counteracted the abnormal membrane responses and calcium elevations induced by the D2R agonist quinpirole or (NPEC-dopamine) in both models[2]. |
| In vivo | Dipraglurant (3-30 mg/kg; single oral dose) exhibits favorable pharmacokinetics and reduces levodopa-induced dyskinesia and muscle tone disturbances without interfering with the efficacy of levodopa treatment in parkinsonian disabled monkeys [1]. |
| Alias | ADX48621 |
| Molecular Weight | 265.29 |
| Formula | C16H12FN3 |
| Cas No. | 872363-17-2 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (150.78 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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