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Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 93 € | In Stock | |
5 mg | 227 € | In Stock | |
10 mg | 329 € | In Stock | |
25 mg | 723 € | In Stock | |
50 mg | 1.064 € | In Stock | |
100 mg | 1.415 € | In Stock | |
1 mL x 10 mM (in DMSO) | 274 € | In Stock |
Description | Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model. |
Targets&IC50 | mGluR5:21 nM |
In vitro | The novel mGlu receptor negative allosteric modulator (NAM) bifunctional agent Dipraglurant(1-10 μM; 15 minutes) counteracted the abnormal membrane responses and calcium elevations induced by the D2R agonist quinpirole or (NPEC-dopamine) in both models[2]. |
In vivo | Dipraglurant (3-30 mg/kg; single oral dose) exhibits favorable pharmacokinetics and reduces levodopa-induced dyskinesia and muscle tone disturbances without interfering with the efficacy of levodopa treatment in parkinsonian disabled monkeys [1]. |
Alias | ADX48621 |
Molecular Weight | 265.29 |
Formula | C16H12FN3 |
Cas No. | 872363-17-2 |
Smiles | Fc1ccc2nc(CCC#Cc3ccccn3)cn2c1 |
Relative Density. | 1.16 g/cm3 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (150.78 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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