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DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $31 | In Stock | |
2 mg | $45 | In Stock | |
5 mg | $77 | In Stock | |
10 mg | $113 | In Stock | |
25 mg | $263 | In Stock | |
50 mg | $488 | In Stock | |
100 mg | $689 | In Stock | |
1 mL x 10 mM (in DMSO) | $85 | In Stock |
Description | DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively. |
Targets&IC50 | GABAA α2 receptor:13 nM (ki), GABAA α5 receptor:2.2 nM (ki), GABAA α1 receptor:ki:10 nM , GABAA α3 receptor:7.5 nM (ki) |
In vivo | DMCM exhibits potent convulsant, proconvulsant, and anxiogenic properties in vivo. At doses of 20-60 mg/kg (i.p.), DMCM induces modest anxiolytic-like effects in γ2I77 mice[2]. |
Molecular Weight | 350.8 |
Formula | C17H19ClN2O4 |
Cas No. | 1215833-62-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 22.5 mg/mL (64.1 mM), Sonication is recommended. DMSO: 9 mg/mL (25.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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