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DMCM hydrochloride
Catalog No. T11061Cas No. 1215833-62-7
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
DMCM hydrochloride
Catalog No. T11061Cas No. 1215833-62-7
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 2 mg | $45 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $113 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $488 | In Stock | |
| 100 mg | $689 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $85 | In Stock |
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Purity:98.95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively. |
| Targets&IC50 | GABAA α2 receptor:13 nM (ki), GABAA α3 receptor:7.5 nM (ki), GABAA α1 receptor:ki:10 nM , GABAA α5 receptor:2.2 nM (ki) |
| In vivo | DMCM exhibits potent convulsant, proconvulsant, and anxiogenic properties in vivo. At doses of 20-60 mg/kg (i.p.), DMCM induces modest anxiolytic-like effects in γ2I77 mice[2]. |
| Molecular Weight | 350.8 |
| Formula | C17H19ClN2O4 |
| Cas No. | 1215833-62-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 22.5 mg/mL (64.1 mM), Sonication is recommended. DMSO: 9 mg/mL (25.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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