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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $34 | In Stock | |
100 mg | $50 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Docosahexaenoic Acid (DHA) is an essential omega-3 fatty acid prevalent in the brain and retina. |
In vitro | When monocytes were differentiated to dendritic cells (DCs) in the presence of docosahexaenoic acid (DHA), the expression of costimulatory and antigen presentation markers was altered in a concentration-dependent way, positively or negatively, depending on the markers tested and the maturation stage of the DCs. DHA-treated, mature DCs showed inhibition of IL-6 expression and IL-10 and IL-12 secretion, and their lymphoproliferative stimulation capacity was impaired [1]. |
In vivo | An experimental model of PD was created by four intraperitoneal injections of MPTP (4 × 20 mg/kg, at 12h intervals). Docosahexaenoic acid was given daily by gavage for 4 weeks (36 mg/kg/day). The number of apoptotic dopaminergic cells significantly increased in MPTP-treated mice compared to controls. Although DHA significantly diminished the number of cell deaths in MPTP-treated mice, it did not improve the decreased motor activity observed in the experimental PD model. Docosahexaenoic acid significantly diminished the amount of cell death in the MPTP+DHA group as compared to the MPTP group [2]. |
Alias | Cervonic acid, DHA |
Molecular Weight | 328.49 |
Formula | C22H32O2 |
Cas No. | 6217-54-5 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 30 mg/mL (91.33 mM), Sonication is recommended. DMSO: 100 mg/mL (304.42 mM), Sonication is recommended. ![]() H2O: 5 mg/mL (15.22 mM) | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
Ethanol/DMSO
DMSO
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