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Dolastatin 10

Name: Dolastatin 10
Brand: TargetMol
SKU: TP1180
Price: 213 USD
Availability: InStock
Rating: 5 (10 reviews)

Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.

Catalog No. TP1180Cas No. 110417-88-4

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Purity:99.55%

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COA HPLC

Dolastatin 10

Catalog No. TP1180Cas No. 110417-88-4

Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$213	In Stock
2 mg	$318	In Stock
5 mg	$538	In Stock
10 mg	$793	In Stock
25 mg	$1,180	In Stock
50 mg	$1,630	In Stock

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Questions

Product Introduction

Bioactivity

Description	Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.
In vitro	Dolastatin 10, a unique pentapeptide isolated from the sea hare Dolabella auricularia, has GI50 values of 10⁻⁵-10⁻⁶ μg/mL (10⁻²-10⁻³ nM) against a similar minipanel of human cell lines, comparable to Auristatin PE. The antibody-drug conjugate (ADC) consists of the anti-CD30 monoclonal antibody cAC10 conjugated to monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.
Alias	NSC 376128, DLS 10

Chemical Properties

Molecular Weight	785.09
Formula	C₄₂H₆₈N₆O₆S
Cas No.	110417-88-4

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (127.37 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2737 mL	6.3687 mL	12.7374 mL	63.6870 mL
5 mM	0.2547 mL	1.2737 mL	2.5475 mL	12.7374 mL
10 mM	0.1274 mL	0.6369 mL	1.2737 mL	6.3687 mL
20 mM	0.0637 mL	0.3184 mL	0.6369 mL	3.1843 mL
50 mM	0.0255 mL	0.1274 mL	0.2547 mL	1.2737 mL
100 mM	0.0127 mL	0.0637 mL	0.1274 mL	0.6369 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc