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DY-46-2
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Catalog No. T62643Cas No. 1105110-83-5
DY-46-2 is a selective non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity for the study of cancer and tumors.
DY-46-2
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Purity: 99.12%
Catalog No. T62643Cas No. 1105110-83-5
DY-46-2 is a selective non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity for the study of cancer and tumors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $155 | 8-10 weeks | |
| 25 mg | $1,420 | 8-10 weeks | |
| 50 mg | $1,850 | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks |
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Purity:99.12%
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Product Introduction
Bioactivity
Chemical Properties
| Description | DY-46-2 is a selective non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity for the study of cancer and tumors. |
| Targets&IC50 | DNMT3A:0.39 μM, G9a:>500 μM, DNMT3B:105 μM, THP1:0.7 μM, DNMT1:13.0 μM, HCT116 cells:0.3 μM |
| In vitro | DY-46-2 (0.1-100 μM, treated for 24, 48 and 72 h) showed inhibitory activity against DNMT3A with an IC50 value of 0.39 μM, and this inhibition increased linearly with increasing DNA concentration. DY-46-2 also showed inhibitory activity against DNMT1, DNMT3B and G9a with IC50 values of 13.0 μM, 105 μM and >500 μM, respectively. In a variety of cancer cell lines, DY-46-2 showed different cell viability inhibitory effects with the following IC50 values: THP-1 cells: 0.7 μM; HCT116 cells: 0.3 μM; U937 cells: 0.7 μM; K562 cells: 0.5 μM; A549 cells: 2.1 μM; DU145 cells: 1.7 μM; PBMC cells: 91 μM. DY-46-2 significantly inhibited the proliferation of cancer cells and showed low cytotoxicity in peripheral blood mononuclear cells (PBMCs). [1] |
| Molecular Weight | 446.48 |
| Formula | C19H22N6O5S |
| Cas No. | 1105110-83-5 |
| Smiles | O=C(NC1=CN=C(C=C1)S(=O)(=O)N)C2=C(OC=3N=CN(C(=O)C32)CCN4CCCC4)C |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (89.59 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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