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CB2R PAM

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Purity:98.17%

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COA HPLC HNMR

CB2R PAM

Catalog No. T37075Cas No. 2244579-87-9

CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.

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Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$179	In Stock
25 mg	$295	In Stock
50 mg	$448	In Stock
100 mg	$659	In Stock
500 mg	$1,380	In Stock

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Product Introduction

Bioactivity

Description	CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.
In vitro	CB2R Positive Allosteric Modulator (PAM) at a concentration of 100 nM notably enhances the capability of CP55940 and 2-AG, without affecting AEA, in promoting [35S]GTPγS binding to CB2 receptors.[1]
In vivo	CB2R PAM (1-20 mg/kg; p.o.) exhibits antinociceptive activity. [1]
Alias	Ec2la

Chemical Properties

Molecular Weight	435.33
Formula	C21H24BrFN2O2
Cas No.	2244579-87-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (103.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2971 mL	11.4855 mL	22.9711 mL	114.8554 mL
5 mM	0.4594 mL	2.2971 mL	4.5942 mL	22.9711 mL
10 mM	0.2297 mL	1.1486 mL	2.2971 mL	11.4855 mL
20 mM	0.1149 mL	0.5743 mL	1.1486 mL	5.7428 mL
50 mM	0.0459 mL	0.2297 mL	0.4594 mL	2.2971 mL
100 mM	0.0230 mL	0.1149 mL	0.2297 mL	1.1486 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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