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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $51 | In Stock | |
5 mg | $122 | In Stock | |
10 mg | $179 | In Stock | |
25 mg | $295 | In Stock | |
50 mg | $448 | In Stock | |
100 mg | $659 | In Stock | |
500 mg | $1,380 | In Stock |
Description | CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain. |
In vitro | CB2R Positive Allosteric Modulator (PAM) at a concentration of 100 nM notably enhances the capability of CP55940 and 2-AG, without affecting AEA, in promoting [35S]GTPγS binding to CB2 receptors.[1] |
In vivo | CB2R PAM (1-20 mg/kg; p.o.) exhibits antinociceptive activity. [1] |
Alias | Ec2la |
Molecular Weight | 435.33 |
Formula | C21H24BrFN2O2 |
Cas No. | 2244579-87-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45.0 mg/mL (103.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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