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EST73502 HCl
Catalog No. T39284Cas No. 2307458-82-6
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
EST73502 HCl
Catalog No. T39284Cas No. 2307458-82-6
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $93 | In Stock | |
| 5 mg | $190 | In Stock | |
| 10 mg | $271 | In Stock | |
| 25 mg | $447 | In Stock | |
| 50 mg | $630 | In Stock | |
| 100 mg | $833 | In Stock | |
| 200 mg | $1,130 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $208 | In Stock |
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Purity:97.66%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity. |
| Targets&IC50 | δ opioid receptor:118 nM(Ki), μ opioid receptor:64 nM(Ki) |
| In vivo | In CD1 male mice, EST73502 (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test. EST73502 (5 mg/kg; i.p.) attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%[1]. |
| Molecular Weight | 388.88 |
| Formula | C19H27ClF2N2O2 |
| Cas No. | 2307458-82-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (128.57 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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