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Ferroptocide
😃Good
Catalog No. T83871Cas No. 2505218-38-0
Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research.
Ferroptocide
😃Good
Catalog No. T83871Cas No. 2505218-38-0
Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $75 | 35 days | |
| 5 mg | $335 | 35 days | |
| 10 mg | $593 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research. |
| Targets&IC50 | ES-2 cells:1.6 μM |
| In vitro | Ferroptocide displays no antibacterial activity (MIC >64 μg/mL) in gram positive (S. aureus) or gram-negative (E. coli) bacteria but has robust anticancer activity in a panel of cancer cell lines and, notably, primary cancer cells freshly isolated from tumor tissues of 15 different patients with diverse metastatic cancers, Ferroptocide with an IC50 = 1.6 μM against ES-2 cells. [1] |
| Molecular Weight | 586.08 |
| Formula | C30H36ClN3O7 |
| Cas No. | 2505218-38-0 |
| Smiles | O[C@@]12[C@]3([C@@H](C)[C@@H](C[C@@H](OC(CCl)=O)[C@]1(C)[C@H](C)CC3)C=4CN5N(CC4)C(=O)N(C5=O)C6=CC=CC=C6)C[C@H](O)C2=O |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | Ethanol: 80 mg/mL(176.64 mM), Sonication is recommended. Methanol: 2 mg/mL(3.41 mM)ï¼›, Sonication is recommended. DMSO: 2 mg/mL(3.41 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
Methanol/DMSO/Ethanol
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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