Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits FLT-1, FLT-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074.
Description | Potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074. |
Targets&IC50 | FGFR4:189 nM (IC50), FGFR3:5.4 nM (Kd), FGFR1:9.2 nM (IC50), FGFR2:6.9 nM (Kd), FGFR4:120 nM (Kd), FGFR3:11.9 nM (IC50), FGFR1:2.8 nM (Kd), FGFR2:6.2 nM (IC50) |
Molecular Weight | 656.61 |
Formula | C32H39Cl2N7O4 |
CAS No. | 1256152-35-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: Soluble
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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FIIN-1 1256152-35-8 FIIN 1 FIIN1 Inhibitor inhibitor inhibit