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Fluorizoline

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Purity:99.52%

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COA HNMR LCMS

Fluorizoline

Catalog No. T31821Cas No. 1362243-70-6

Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has been used in studies of leukemia.

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Pack Size	Price	Availability	Quantity
2 mg	$58	In Stock

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Product Introduction

Bioactivity

Description	Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has been used in studies of leukemia.
In vitro	In primary CLL cells, Fluorizoline (1.25 to 20 μM; 24 hours) significantly reduced cell viability and induced apoptosis in a dose-dependent manner[1].

Chemical Properties

Molecular Weight	362.20
Formula	C15H8Cl2F3NS
Cas No.	1362243-70-6

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (82.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7609 mL	13.8045 mL	27.6091 mL	138.0453 mL
5 mM	0.5522 mL	2.7609 mL	5.5218 mL	27.6091 mL
10 mM	0.2761 mL	1.3805 mL	2.7609 mL	13.8045 mL
20 mM	0.1380 mL	0.6902 mL	1.3805 mL	6.9023 mL
50 mM	0.0552 mL	0.2761 mL	0.5522 mL	2.7609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc