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FR-167356
🥰Excellent
Catalog No. T27371Cas No. 174185-16-1
Alias FR167356, FR 167356
FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces bone metastasis of B16-F10 cells.
FR-167356
🥰Excellent
Purity: 99.19%
Catalog No. T27371Alias FR167356, FR 167356Cas No. 174185-16-1
FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces bone metastasis of B16-F10 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $118 | In Stock | |
| 5 mg | $287 | In Stock | |
| 10 mg | $392 | In Stock | |
| 25 mg | $593 | In Stock | |
| 50 mg | $798 | In Stock | |
| 100 mg | $1,050 | In Stock | |
| 200 mg | $1,390 | In Stock |
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Purity:99.19%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces bone metastasis of B16-F10 cells. |
| In vivo | In male C57BL/6 mice with B16-F10 xenografts, FR-167356 (200 mg/kg) reduces bone metastasis, inhibits tumor growth, and reduces the expression of MMP9[1]. |
| Alias | FR167356, FR 167356 |
| Molecular Weight | 378.25 |
| Formula | C19H17Cl2NO3 |
| Cas No. | 174185-16-1 |
| Smiles | C(C)(C)(O)C=1C=2C(=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=CC2)OC1C |
| Relative Density. | 1.385 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (7.08 mM)  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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