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Gefarnate

🥰Excellent
Catalog No. T7099Cas No. 51-77-4

Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.

Gefarnate

Gefarnate

🥰Excellent
Purity: 97.10%
Catalog No. T7099Cas No. 51-77-4
Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.
Pack SizePriceAvailabilityQuantity
100 mg$38In Stock
200 mg$56In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:97.10%
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Product Introduction

Bioactivity
Description
Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.
In vivo
Gefarnate stimulated mucin-like glycoprotein secretion in conjunctival tissue in a dose-dependent manner. In the rabbit dry-eye model, application of gefarnate ointment to the eyes resulted in a dose-dependent decrease in rose bengal permeability in the cornea, with the effect being significant at concentrations of ≥0.3%. In the cat dry-eye model, application of gefarnate ointment resulted in a significant decrease in the corneal fluorescein staining score[1].
Animal Research
Conjunctival tissue isolated from rabbits was treated with gefarnate. Mucin-like glycoprotein was detected in the culture supernatant by an enzyme-linked lectin assay. Gefarnate ointment was topically applied to eyes once daily for 7 days in the rabbit dry-eye model, in which the lacrimal glands, Harderian gland, and nictitating membrane were removed, or for 4 weeks in the cat dry-eye model, in which the lacrimal gland and nictitating membrane were removed. Corneal epithelial damage was evaluated by measurement of corneal permeability by rose bengal in the rabbit model or by fluorescein staining in the cat model[1].
Chemical Properties
Molecular Weight400.64
FormulaC27H44O2
Cas No.51-77-4
SmilesC(=C/CCC(OC/C=C(/CCC=C(C)C)\C)=O)(\CC/C=C(/CCC=C(C)C)\C)/C
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (249.60 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4960 mL12.4800 mL24.9601 mL124.8003 mL
5 mM0.4992 mL2.4960 mL4.9920 mL24.9601 mL
10 mM0.2496 mL1.2480 mL2.4960 mL12.4800 mL
20 mM0.1248 mL0.6240 mL1.2480 mL6.2400 mL
50 mM0.0499 mL0.2496 mL0.4992 mL2.4960 mL
100 mM0.0250 mL0.1248 mL0.2496 mL1.2480 mL

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