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Gestrinone

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Purity:99.21%

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COA HPLC HNMR

Gestrinone

Catalog No. T7223Cas No. 16320-04-0

Gestrinone (R 2323) is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM.

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Pack Size	Price	Availability
5 mg	$51	In Stock
10 mg	$82	In Stock
25 mg	$145	In Stock
50 mg	$215	In Stock
1 mL x 10 mM (in DMSO)	$60	In Stock

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Product Introduction

Bioactivity

Description	Gestrinone (R 2323) is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM.
In vivo	Mifepristone combined with gestrinone had satisfactory clinical therapeutic effects on endometriosis by reducing hormone levels and improving pregnancy outcomes[1].
Animal Research	A total of 150 endometriotic patients were randomly divided into a control group and a treatment group (n=75). The control group began to orally take gestrinone capsules on the second day after menstruation started (2.5 mg/time, twice/week). The treatment group orally took mifepristone tablets (12.5 mg/time, once/day), and the dosage and administration of gestrinone capsules were the same as those of the control group. After 24 weeks of consecutive treatment, the clinical therapeutic effects of the two groups were assessed, and the pelvic symptom score, clinical sign score, serum sex hormone levels and pregnancy outcomes were compared[1].
Alias	R 2323

Chemical Properties

Molecular Weight	308.41
Formula	C21H24O2
Cas No.	16320-04-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (162.12 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2424 mL	16.2122 mL	32.4244 mL	162.1219 mL
5 mM	0.6485 mL	3.2424 mL	6.4849 mL	32.4244 mL
10 mM	0.3242 mL	1.6212 mL	3.2424 mL	16.2122 mL
20 mM	0.1621 mL	0.8106 mL	1.6212 mL	8.1061 mL
50 mM	0.0648 mL	0.3242 mL	0.6485 mL	3.2424 mL
100 mM	0.0324 mL	0.1621 mL	0.3242 mL	1.6212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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