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GSK205
Catalog No. T11480Cas No. 1263068-83-2
GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $156 | In Stock | |
| 10 mg | $272 | In Stock | |
| 25 mg | $587 | In Stock | |
| 50 mg | $993 | In Stock | |
| 100 mg | $1,730 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $165 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain. |
| In vitro | In T3-F442A adipocytes, GSK205 (5 μM; 4 days) resulted in increased expression of thermogenic genes and was accompanied by a decrease in the proinflammatory gene program[1]. |
| In vivo | In male C57BL/6J mice on a high-fat diet, GSK205 (10 mg/kg; intraperitoneal injection; twice daily; for 7 days) caused a reduced expression of proinflammatory chemokines, macrophage markers, and Tnfa in EPI fat. It also significantly improved glucose tolerance in diet-induced obese (DIO) mice[1]. |
| Molecular Weight | 481.45 |
| Formula | C24H25BrN4S |
| Cas No. | 1263068-83-2 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (207.71 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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