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GSK2807 Trifluoroacetate

GSK2807 Trifluoroacetate
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).
Catalog No. T11486Cas No. 2245255-66-5
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Purity:99.95%
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GSK2807 Trifluoroacetate

Catalog No. T11486Cas No. 2245255-66-5

GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$84In Stock
5 mg$197In Stock
10 mg$289In Stock
25 mg$488In Stock
50 mgInquiryIn Stock
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Product Introduction

Bioactivity
Description
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).
Targets&IC50
SMYD3:130 nM, SMYD3:14 nM (ki)
In vitro
GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM). A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively) [1].
Chemical Properties
Molecular Weight566.53
FormulaC21H33F3N8O7
Cas No.2245255-66-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (88.26 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.7651 mL8.8257 mL17.6513 mL88.2566 mL
5 mM0.3530 mL1.7651 mL3.5303 mL17.6513 mL
10 mM0.1765 mL0.8826 mL1.7651 mL8.8257 mL
20 mM0.0883 mL0.4413 mL0.8826 mL4.4128 mL
50 mM0.0353 mL0.1765 mL0.3530 mL1.7651 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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