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GSK319347A

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Purity:98.42%

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COA HNMR HPLC

GSK319347A

Catalog No. T15558Cas No. 862812-98-4

GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.

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Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$155	In Stock
10 mg	$268	In Stock
25 mg	$563	In Stock
50 mg	$958	In Stock
100 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$358	In Stock

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Product Introduction

Bioactivity

Description	GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.
In vitro	GSK319347A (Compound 1) inhibits the TBK1 enzyme with an IC50 of 93 nM, demonstrating good cell potency at 72 nM. Additionally, IKK-3 Inhibitor shows excellent selectivity against cell-cycle kinases CDK2 and AurB[1]. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM[1].

Chemical Properties

Molecular Weight	469.53
Formula	C22H19N3O5S2
Cas No.	862812-98-4

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (85.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1298 mL	10.6489 mL	21.2979 mL	106.4895 mL
5 mM	0.4260 mL	2.1298 mL	4.2596 mL	21.2979 mL
10 mM	0.2130 mL	1.0649 mL	2.1298 mL	10.6489 mL
20 mM	0.1065 mL	0.5324 mL	1.0649 mL	5.3245 mL
50 mM	0.0426 mL	0.2130 mL	0.4260 mL	2.1298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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