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HC067047 Hydrochloride(883031-03-6 free base)

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Purity:99.68%

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COA HNMR HPLC

HC067047 Hydrochloride(883031-03-6 free base)

Catalog No. T4680LCas No. 1481646-76-7

HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 486 nM, 133nM, and 17 nM, respectively.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
1 mg	$133	In Stock
5 mg	$302	In Stock
10 mg	$453	In Stock
25 mg	$747	In Stock
50 mg	$1,050	In Stock
100 mg	$1,420	In Stock
500 mg	$2,830	In Stock
1 mL x 10 mM (in DMSO)	$381	In Stock

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Product Introduction

Bioactivity

Description	HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 486 nM, 133nM, and 17 nM, respectively.
In vitro	TRPV4 is a hyperglycemia-related factor that can inhibit cell proliferation and promote cell apoptosis by activating the MAPK signaling pathway in HEI-OC1 cells[1].
In vivo	HC-067047 increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis[2].

Chemical Properties

Molecular Weight	507.98
Formula	C26H29ClF3N3O2
Cas No.	1481646-76-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (108.27 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9686 mL	9.8429 mL	19.6858 mL	98.4291 mL
5 mM	0.3937 mL	1.9686 mL	3.9372 mL	19.6858 mL
10 mM	0.1969 mL	0.9843 mL	1.9686 mL	9.8429 mL
20 mM	0.0984 mL	0.4921 mL	0.9843 mL	4.9215 mL
50 mM	0.0394 mL	0.1969 mL	0.3937 mL	1.9686 mL
100 mM	0.0197 mL	0.0984 mL	0.1969 mL	0.9843 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc