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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | $29 | In Stock | |
1 mL x 10 mM (in DMSO) | $51 | In Stock |
Description | Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kinase II inhibitor (IC50: 0.74 μM). |
Targets&IC50 | CK2:0.74 μM |
In vitro | Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation. Hematein (50 and 100 μM; 48 hours) causes apoptosis in A427 lung cancer cells. Hematein (10-100 μM; 14 days) inhibits cell growth in A427 lung cancer cells [1]. |
In vivo | In A427 lung cancer cell xenografts, Hematein (i.p.; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth [1]. |
Alias | Hydroxybrasilein |
Molecular Weight | 300.26 |
Formula | C16H12O6 |
Cas No. | 475-25-2 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5.5 mg/mL (18.32 mM), Sonication is recommended. ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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