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Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting NF-κB activation.
Pack Size | Price | Availability | Quantity |
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50 mg | Inquiry | In Stock | |
100 mg | Inquiry | In Stock |
Description | Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting NF-κB activation. |
In vivo | Hesperidin methylchalcone (HMC) in a mouse model of gout arthritis induced by intra-articular injection of MSU (100 μg/10 μL).?Orally given HMC (3-30 mg/kg, 100 μL) reduced in a dose-dependent manner the MSU-induced hyperalgesia (44%, p 0.05), edema (54%, p 0.05), and leukocyte infiltration (70%, p 0.05).?HMC (30 mg/kg) inhibited MSU-induced infiltration of LysM-eGFP+ cells (81%, p 0.05), synovitis (76%, p 0.05), and oxidative stress (increased GSH, FRAP, and ABTS by 62, 78, and 73%, respectively;?reduced O2- and NO by 89 and 48%, p 0.05) and modulated cytokine production (reduced IL-1β, TNF-α, IL-6, and IL-10 by 35, 72, 37, and 46%, respectively, and increased TGF-β by 90%, p 0.05).?HMC also inhibited MSU-induced NF-κB activation (41%, p 0.05), gp91phox (66%, p 0.05) and NLRP3 inflammasome components mRNA expression in vivo (72, 77, 71, and 73% for NLRP3, ASC, pro-caspase-1, and pro-IL-1 β, respectively, p 0.05), and induced Nrf2/HO-1 mRNA expression (3.9- and 5.1-fold increase, respectively, p 0.05).?HMC (30, 100, and 300 μM) did not inhibit IL-1β secretion by macrophages primed by LPS and challenged with MSU (450 μg/mL), demonstrating that the anti-inflammatory effect of HMC in gout arthritis depends on inhibiting NF-κB but not on direct inhibition of inflammasome[1]. |
Molecular Weight | 624.59 |
Formula | C29H36O15 |
Cas No. | 24292-52-2 |
Relative Density. | 1.3090 g/cm3 (Estimated) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (16.01 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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