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Indatuximab ravtansine
😃Good
Catalog No. T9901A-224Cas No. 1238517-16-2
Alias nBT062-DM4, BT-062
Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) (Antibody-Drug Conjugates (ADCs)) that consists of a murine-human chimeric form based on B-B4, which specifically targets CD138, linked via a disulfide bond to the maytansinoid drug DM4. It exhibits antitumor activity.
Indatuximab ravtansine
Indatuximab ravtansine
😃Good
Catalog No. T9901A-224Alias nBT062-DM4, BT-062Cas No. 1238517-16-2
Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) (Antibody-Drug Conjugates (ADCs)) that consists of a murine-human chimeric form based on B-B4, which specifically targets CD138, linked via a disulfide bond to the maytansinoid drug DM4. It exhibits antitumor activity.
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| 5 mg | Inquiry | Backorder |
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Disitamab vedotin
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Brentuximab vedotin
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Trastuzumab emtansine
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Product Introduction
Bioactivity
Chemical Properties
| Description | Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) (Antibody-Drug Conjugates (ADCs)) that consists of a murine-human chimeric form based on B-B4, which specifically targets CD138, linked via a disulfide bond to the maytansinoid drug DM4. It exhibits antitumor activity. |
| In vitro | Indatuximab ravtansine demonstrated cytotoxic effects in RPMI 8226, MOLP-8, and U266 cell lines (with significant CD138 expression) at concentrations ranging from 1 pM to 100 nM over five days. The IC50 values for RPMI 8226, MOLP-8, and U266 were 200 pM, 40 pM, and 20 pM, respectively. |
| In vivo | Indatuximab ravtansine (5.3-21.2 mg/kg; intravenous injection; single dose) suppresses tumor growth in multiple myeloma and enhances host survival in vivo. |
| Alias | nBT062-DM4, BT-062 |
| Cas No. | 1238517-16-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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