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Isbogrel

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Purity:97.06%

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COA HNMR HPLC LCMS

Isbogrel

Catalog No. T27630Cas No. 89667-40-3

Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks and thrombosis.

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Pack Size	Price	Availability
1 mg	$350	In Stock
5 mg	$828	In Stock
10 mg	$1,130	In Stock
25 mg	$1,590	In Stock
50 mg	$1,980	In Stock
100 mg	$2,500	In Stock

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Product Introduction

Bioactivity

Description	Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks and thrombosis.
In vivo	CV-4151 significantly inhibited photochemically induced MCA thrombosis by oral (1 and 10 mg/kg) and intravenous (1 mg/kg) administration.[2] CV-4151 (10 mg/kg, p.o.), furthermore, significantly reduced the infarct size and inhibited the increase in lactate content. CV-4151 might be a useful drug for the treatment of cerebral thrombosis and for the prevention of cerebral infarction.[2]
Alias	CV4151, CV-4151, CV 4151

Chemical Properties

Molecular Weight	281.35
Formula	C18H19NO2
Cas No.	89667-40-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (195.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5543 mL	17.7715 mL	35.5429 mL	177.7146 mL
5 mM	0.7109 mL	3.5543 mL	7.1086 mL	35.5429 mL
10 mM	0.3554 mL	1.7771 mL	3.5543 mL	17.7715 mL
20 mM	0.1777 mL	0.8886 mL	1.7771 mL	8.8857 mL
50 mM	0.0711 mL	0.3554 mL	0.7109 mL	3.5543 mL
100 mM	0.0355 mL	0.1777 mL	0.3554 mL	1.7771 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc