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IWP L6

🥰Excellent
Catalog No. T2683Cas No. 1427782-89-5
Alias Porcn Inhibitor III, Porcn Inhibitor III, IWP-L6

IWP L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with an EC50 of 0.5 nM.

IWP L6

IWP L6

🥰Excellent
Purity: 100%
Catalog No. T2683Alias Porcn Inhibitor III, Porcn Inhibitor III, IWP-L6Cas No. 1427782-89-5
IWP L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with an EC50 of 0.5 nM.
Pack SizePriceAvailabilityQuantity
5 mg$41In Stock
10 mg$62In Stock
25 mg$116In Stock
50 mg$198In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
IWP L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with an EC50 of 0.5 nM.
Targets&IC50
Porcn:0.5 nM(EC50)
In vitro
In zebrafish embryos, IWP-L6 significantly inhibits the formation of posterior vertebrae, which is dependent on Wnt/β-catenin. IWP-L6 exhibits stability in human plasma (>24 hours) but shows rapid metabolism in rat plasma (half-life: 190 minutes), mouse plasma (half-life: 2 minutes), and mouse liver S9 fractions.
In vivo
In cultured embryonic kidneys, IWP-L6 can reversibly block the Wnt signaling pathway, thereby inhibiting Wnt-mediated branching morphogenesis. It also impedes the phosphorylation of Dvl2, a cytoplasmic effector of the Wnt pathway, in HEK293 cells.
AliasPorcn Inhibitor III, Porcn Inhibitor III, IWP-L6
Chemical Properties
Molecular Weight472.58
FormulaC25H20N4O2S2
Cas No.1427782-89-5
SmilesO=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccccc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.73 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1160 mL10.5802 mL21.1604 mL105.8022 mL
5 mM0.4232 mL2.1160 mL4.2321 mL21.1604 mL
10 mM0.2116 mL1.0580 mL2.1160 mL10.5802 mL

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