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IWP L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with an EC50 of 0.5 nM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $41 | In Stock | |
10 mg | $62 | In Stock | |
25 mg | $116 | In Stock | |
50 mg | $198 | In Stock |
Description | IWP L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with an EC50 of 0.5 nM. |
Targets&IC50 | Porcn:0.5 nM(EC50) |
In vitro | In zebrafish embryos, IWP-L6 significantly inhibits the formation of posterior vertebrae, which is dependent on Wnt/β-catenin. IWP-L6 exhibits stability in human plasma (>24 hours) but shows rapid metabolism in rat plasma (half-life: 190 minutes), mouse plasma (half-life: 2 minutes), and mouse liver S9 fractions. |
In vivo | In cultured embryonic kidneys, IWP-L6 can reversibly block the Wnt signaling pathway, thereby inhibiting Wnt-mediated branching morphogenesis. It also impedes the phosphorylation of Dvl2, a cytoplasmic effector of the Wnt pathway, in HEK293 cells. |
Alias | Porcn Inhibitor III, Porcn Inhibitor III, IWP-L6 |
Molecular Weight | 472.58 |
Formula | C25H20N4O2S2 |
Cas No. | 1427782-89-5 |
Smiles | O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccccc1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.73 mg/mL (10 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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