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IWP L6

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Purity:100%

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COA HPLC HNMR

IWP L6

Catalog No. T2683Cas No. 1427782-89-5

IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).

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Pack Size	Price	Availability
5 mg	$41	In Stock
10 mg	$62	In Stock
25 mg	$116	In Stock
50 mg	$198	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock

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Product Introduction

Bioactivity

Description	IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
In vitro	In zebrafish embryos, IWP-L6 significantly inhibits the formation of posterior vertebrae, which is dependent on Wnt/β-catenin. IWP-L6 exhibits stability in human plasma (>24 hours) but shows rapid metabolism in rat plasma (half-life: 190 minutes), mouse plasma (half-life: 2 minutes), and mouse liver S9 fractions.
In vivo	In cultured embryonic kidneys, IWP-L6 can reversibly block the Wnt signaling pathway, thereby inhibiting Wnt-mediated branching morphogenesis. It also impedes the phosphorylation of Dvl2, a cytoplasmic effector of the Wnt pathway, in HEK293 cells.
Alias	Porcn Inhibitor III, IWP-L6, Porcn Inhibitor III

Chemical Properties

Molecular Weight	472.58
Formula	C25H20N4O2S2
Cas No.	1427782-89-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.73 mg/mL (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1160 mL	10.5802 mL	21.1604 mL	105.8022 mL
5 mM	0.4232 mL	2.1160 mL	4.2321 mL	21.1604 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc