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Porcn-IN-1

Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).

Catalog No. T4438Cas No. 2036044-77-4

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Purity:99.61%

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COA LCMS HPLC HNMR

Porcn-IN-1

Catalog No. T4438Cas No. 2036044-77-4

Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$198	In Stock
25 mg	$346	In Stock
50 mg	$516	In Stock
100 mg	$736	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

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Product Introduction

Bioactivity

Description	Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
Targets&IC50	Porcupine:0.5 Nm
In vitro	Porcupine, an enzyme, facilitates the attachment of palmitoleate to a serine residue within Wnt proteins, essential for their secretion. Porcupine-IN-1 exhibits potency comparable to the clinical compound LGK974 in a cell-based STF reporter gene assay and effectively inhibits the secretion of Wnt3A, thereby confirming its role as a porcupine inhibitor[1].
In vivo	Porcupine-IN-1 exhibits moderate metabolic clearance in human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg), while demonstrating high clearance rates in mouse liver microsomes (109 mL/min/kg)[1].
Cell Research	HEK293T cells are transfected with pLinbin-Wnt3A plasmid or vehicle control. The HEK293T cells are then treated with or without compounds (Porcupine-IN-1). Western Blot is used after 48 h to analyze both the cell lysis and culture medium[1].
Alias	Porcupine-IN-1

Chemical Properties

Molecular Weight	410.44
Formula	C₂₅H₁₉FN₄O
Cas No.	2036044-77-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (243.64 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4364 mL	12.1820 mL	24.3641 mL	121.8205 mL
5 mM	0.4873 mL	2.4364 mL	4.8728 mL	24.3641 mL
10 mM	0.2436 mL	1.2182 mL	2.4364 mL	12.1820 mL
20 mM	0.1218 mL	0.6091 mL	1.2182 mL	6.0910 mL
50 mM	0.0487 mL	0.2436 mL	0.4873 mL	2.4364 mL
100 mM	0.0244 mL	0.1218 mL	0.2436 mL	1.2182 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc