Shopping Cart
- Remove All
Your shopping cart is currently empty
Porcn-IN-1
Catalog No. T4438Cas No. 2036044-77-4
Alias Porcupine-IN-1
Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
Porcn-IN-1
Catalog No. T4438Alias Porcupine-IN-1Cas No. 2036044-77-4
Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $163 | In Stock | |
| 25 mg | $297 | In Stock | |
| 50 mg | $446 | In Stock | |
| 100 mg | $579 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $113 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Porcn-IN-1"
IWP-2
IWP2
T2702686770-61-6
IWP-2 is a Wnt pathway inhibitor (IC50=27 nM) and an ATP-competitive CK1δ inhibitor (IC50=40 nM for M82FCK1δ). IWP-2 inhibits self-renewal of embryonic stem cells and has been used in stem cell and organoid research.
- $43
Size
QTY
Wnt-C59
Cited
C59
T22421243243-89-1
Wnt-C59 (C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
- $33
Size
QTY
CitedLGK974 Cited
WNT974, NVP-LGK974, LGK-974, LGK 974
T26181243244-14-5
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck.
- $41
Size
QTY
CitedIWP L6
Porcn Inhibitor III, Porcn Inhibitor III, IWP-L6
T26831427782-89-5
IWP L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with an EC50 of 0.5 nM.
- $41
Size
QTY
IWP-O1
T53422074607-48-8
IWP-O1, a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
- $33
Size
QTY
ETC-159
ETC-1922159, ETC159, ETC 159
T40431638250-96-0
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
- $43
Size
QTY
GNF-6231
T114441243245-18-2
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
- $30
Size
QTY
WHN-88
T898812490686-86-5
WHN-88, a Porcupine (PORCN) inhibitor, disrupts the palmitoylation of Wnt ligands, which inhibits their secretion and subsequent Wnt/β-catenin signaling. This compound has shown efficacy in reducing cancer cell stemness and suppressing the progression and development of breast tumors in MMTV-Wnt1 transgenic mice.
- Inquiry Price
Size
QTY
Select Batch
Purity:99.61%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM). |
| Targets&IC50 | Porcupine:0.5 Nm |
| In vitro | Porcupine, an enzyme, facilitates the attachment of palmitoleate to a serine residue within Wnt proteins, essential for their secretion. Porcupine-IN-1 exhibits potency comparable to the clinical compound LGK974 in a cell-based STF reporter gene assay and effectively inhibits the secretion of Wnt3A, thereby confirming its role as a porcupine inhibitor[1]. |
| In vivo | Porcupine-IN-1 exhibits moderate metabolic clearance in human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg), while demonstrating high clearance rates in mouse liver microsomes (109 mL/min/kg)[1]. |
| Cell Research | HEK293T cells are transfected with pLinbin-Wnt3A plasmid or vehicle control. The HEK293T cells are then treated with or without compounds (Porcupine-IN-1). Western Blot is used after 48 h to analyze both the cell lysis and culture medium[1]. |
| Alias | Porcupine-IN-1 |
| Molecular Weight | 410.44 |
| Formula | C25H19FN4O |
| Cas No. | 2036044-77-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (243.64 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Porcn-IN-1 | purchase Porcn-IN-1 | Porcn-IN-1 cost | order Porcn-IN-1 | Porcn-IN-1 chemical structure | Porcn-IN-1 in vivo | Porcn-IN-1 in vitro | Porcn-IN-1 formula | Porcn-IN-1 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.