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GNF-6231

GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.

Catalog No. T11444Cas No. 1243245-18-2

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Purity:100%

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COA HPLC HNMR

GNF-6231

Catalog No. T11444Cas No. 1243245-18-2

GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$43	In Stock
10 mg	$67	In Stock
25 mg	$117	In Stock
50 mg	$190	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Product Introduction

Bioactivity

Description	GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
In vitro	GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested[1].
In vivo	GNF-6231 has favorable potency and a PK profile across preclinical species upon oral administration. The reference for orally in MMTV-Wnt1 tumor-bearing mice is dosed at 3 mg/kg. GNF-6231 showed very robust dose-related antitumor efficacy[1].

Chemical Properties

Molecular Weight	448.49
Formula	C₂₄H₂₅FN₆O₂
Cas No.	1243245-18-2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 36 mg/mL (80.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2297 mL	11.1485 mL	22.2970 mL	111.4852 mL
5 mM	0.4459 mL	2.2297 mL	4.4594 mL	22.2970 mL
10 mM	0.2230 mL	1.1149 mL	2.2297 mL	11.1485 mL
20 mM	0.1115 mL	0.5574 mL	1.1149 mL	5.5743 mL
50 mM	0.0446 mL	0.2230 mL	0.4459 mL	2.2297 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc