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GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $30 | In Stock | |
5 mg | $43 | In Stock | |
10 mg | $67 | In Stock | |
25 mg | $117 | In Stock | |
50 mg | $190 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. |
In vitro | GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested[1]. |
In vivo | GNF-6231 has favorable potency and a PK profile across preclinical species upon oral administration. The reference for orally in MMTV-Wnt1 tumor-bearing mice is dosed at 3 mg/kg. GNF-6231 showed very robust dose-related antitumor efficacy[1]. |
Molecular Weight | 448.49 |
Formula | C24H25FN6O2 |
Cas No. | 1243245-18-2 |
Smiles | CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(C)c2)-c2ccnc(F)c2)nc1 |
Relative Density. | 1.306 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 36 mg/mL (80.3 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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