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JTE-907

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Purity:100%

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COA HNMR HPLC

JTE-907

Catalog No. T19705Cas No. 282089-49-0

JTE-907 is a CB2 receptor inverse agonist with high selectivity and oral activity.JTE-907 exhibits anti-inflammatory activity in vivo.

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Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$128	In Stock
10 mg	$197	In Stock
25 mg	$347	In Stock
50 mg	$516	In Stock
100 mg	$736	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock

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Product Introduction

Bioactivity

Description	JTE-907 is a CB2 receptor inverse agonist with high selectivity and oral activity.JTE-907 exhibits anti-inflammatory activity in vivo.
In vitro	JTE 907 acts as a Gq-coupled agonist in islets to stimulate insulin secretion and maintain β-cell mass in a GPR55-independent fashion. JTE 907 (10 μM) significantly stimulated insulin secretion from islets isolated from human donors and islets from Gpr55+/+ and Gpr55-/- mice. These stimulatory effects were accompanied by significant elevations of IP1 and [Ca2+]i, but there were no changes in cAMP generation. JTE 907 also significantly reduced cytokine-induced apoptosis in human and mouse islets and promoted human β-cell proliferation.[4]
Alias	JTE 907

Chemical Properties

Molecular Weight	438.47
Formula	C24H26N2O6
Cas No.	282089-49-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (256.6 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2807 mL	11.4033 mL	22.8066 mL	114.0329 mL
5 mM	0.4561 mL	2.2807 mL	4.5613 mL	22.8066 mL
10 mM	0.2281 mL	1.1403 mL	2.2807 mL	11.4033 mL
20 mM	0.1140 mL	0.5702 mL	1.1403 mL	5.7016 mL
50 mM	0.0456 mL	0.2281 mL	0.4561 mL	2.2807 mL
100 mM	0.0228 mL	0.1140 mL	0.2281 mL	1.1403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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