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K-975

Name: K-975
Brand: TargetMol
SKU: T9954
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.

Catalog No. T9954Cas No. 2563855-03-6

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Purity:99.51%

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COA HPLC HNMR

K-975

Catalog No. T9954Cas No. 2563855-03-6

K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$528	In Stock
50 mg	$747	Backorder
1 mL x 10 mM (in DMSO)	$178	In Stock

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Product Introduction

Bioactivity

Description	K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.
In vitro	K-975 inhibits the cell proliferation of NRF2-non-expressing malignant pleural mesothelioma (MPM) cell lines, protein-protein interaction (PPI) between Halo-TAZ and TEAD1/4 and Halo-YAP and endogenous TEAD1/4 in NCl-H226 cells and the reporter activity in NCl-H661/CTGF-Luc cells with the maximum of ~70%, at concentration of 0.1-10000 nM at 144 h and 24 h, respectively [1]. K-975 decreases the expression of IGFBP3, CTGF and NPPB mRNAs, and increases the expression of FBXO32 mRNA in NCl-H226 cells [1].
In vivo	K-975 (10-300 mg/kg; p.o. twice daily for 14 days) suppresses tumor growth by inhibiting TEAD-YAP1/TAZ signaling in MPM xenograft mouse models [1].

Chemical Properties

Molecular Weight	287.74
Formula	C₁₆H₁₄ClNO₂
Cas No.	2563855-03-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 215 mg/mL (747.20 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4754 mL	17.3768 mL	34.7536 mL	173.7680 mL
5 mM	0.6951 mL	3.4754 mL	6.9507 mL	34.7536 mL
10 mM	0.3475 mL	1.7377 mL	3.4754 mL	17.3768 mL
20 mM	0.1738 mL	0.8688 mL	1.7377 mL	8.6884 mL
50 mM	0.0695 mL	0.3475 mL	0.6951 mL	3.4754 mL
100 mM	0.0348 mL	0.1738 mL	0.3475 mL	1.7377 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

K975YAP1Cys359pleuralTAZinhibitK 975Yes-associated proteinK-975YAPInhibitorantitumormalignantTEADmesotheliomacancer