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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $3,200 | Backorder |
Description | KT5823 is a selective and potent cGMP-dependent protein kinase (PKG) inhibitor with inhibitory effects on PKA and PKC.KT5823 increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression and iodide ion uptake by modulating sodium iodide symporter protein expression and activity in thyroid cells. KT5823 induces apoptosis. |
In vitro | A staurosporine-related protein kinase inhibitor, KT5823, increases expression of the sodium/iodide symporter (NIS) and iodide uptake in thyroid cells induced by thyroid-stimulating hormone [3]. It arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation [2]. |
Molecular Weight | 495.53 |
Formula | C29H25N3O5 |
Cas No. | 126643-37-6 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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