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L-745870
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Catalog No. T11799LCas No. 158985-00-3
L-745870 is an orally active, selective, and efficient dopamine D4 receptor antagonist that crosses the blood-brain barrier. It also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors, useful in neurological disease studies.
L-745870
🥰Excellent
Catalog No. T11799LCas No. 158985-00-3
L-745870 is an orally active, selective, and efficient dopamine D4 receptor antagonist that crosses the blood-brain barrier. It also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors, useful in neurological disease studies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $59 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $329 | In Stock | |
| 100 mg | $478 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $63 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-745870 is an orally active, selective, and efficient dopamine D4 receptor antagonist that crosses the blood-brain barrier. It also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors, useful in neurological disease studies. |
| Targets&IC50 | D3 receptor (human):2300 nM (Ki), D4 receptor (human):0.43 nM (Ki), D2 receptor (human):960 nM (Ki) |
| In vitro | L-745870 binds specifically to the human dopamine D4 receptor with a binding affinity (Ki) of 0.43 nM. L-745870 (0.1-1 μM) exhibits D4 receptor antagonist activity, reversing dopamine (1 μM) -mediated adenylate cyclase inhibition in hD4HEK and hD4CHO cells. [1] |
| In vivo | L-745870 (0, 1, or 2 μg/5 μl,icv injection) acts on dopamine D4 receptors to reduce sucrose consumption in a dose-dependent manner in hedonic-fed rat models. [2] L-745870 (5 and 10 mg/kg, systemic injection) inhibited PFC slow rhythm (delta, 2-4 Hz) and enhanced HPCθ in rats. [3] |
| Molecular Weight | 326.82 |
| Formula | C18H19ClN4 |
| Cas No. | 158985-00-3 |
| Smiles | ClC1=CC=C(C=C1)N2CCN(CC3=CNC=4N=CC=CC43)CC2 |
| Relative Density. | 1.31 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16 mg/mL (48.96 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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