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L-745870 trihydrochloride
🥰Excellent
Catalog No. T22904Cas No. 866021-03-6
Alias L-745,870 trihydrochloride
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
L-745870 trihydrochloride
🥰Excellent
Purity: 97.52%
Catalog No. T22904Alias L-745,870 trihydrochlorideCas No. 866021-03-6
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $127 | In Stock | |
| 25 mg | $292 | In Stock | |
| 50 mg | $418 | In Stock | |
| 100 mg | $592 | In Stock | |
| 200 mg | $783 | In Stock |
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- $45
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Purity:97.52%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. |
| Targets&IC50 | D3 receptor:2300 nM (Ki), D4 receptor:4.3 nM (Ki), D2 receptor:960 nM (Ki) |
| In vivo | L-745870 has favorable pharmacokinetic properties in both rats and monkeys, and shows excellent brain permeability and a high brain-to-plasma ratio in rats [1]. L-745870 (10 mg/kg p.o.) at 30 mg/kg caused mild sedation and extrapyramidal motor symptoms, especially bradykinesia, following oral administration to squirrel monkeys. Lower doses of L-745870 had no apparent behavioral effects in monkeys [1]. |
| Alias | L-745,870 trihydrochloride |
| Molecular Weight | 436.21 |
| Formula | C18H22Cl4N4 |
| Cas No. | 866021-03-6 |
| Smiles | ClC1=CC=C(C=C1)N2CCN(CC2)CC3=CNC4=C3C=CC=N4.Cl.Cl.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (114.62 mM)  H2O: < 40 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
α-adrenoceptorsSigmareceptorSigma receptororallyL-745870 trihydrochlorideL-745870 TrihydrochlorideL745870 trihydrochlorideL745870 TrihydrochlorideL-745870L745870L-745,870 TrihydrochlorideL-745,870L 745870 trihydrochlorideL 745870 TrihydrochlorideL 745870InhibitorinhibitDopamineReceptorDopamine ReceptorD4-receptorbrain-penetrantAntipsychoticAdrenergicReceptorAdrenergic Receptor5HTReceptor5-HT25HT Receptor
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