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Lariciresinol

Catalog No. TN1853Cas No. 27003-73-2

Lariciresinol is an enterolignan precursor, it possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious diseases in humans. Dietary lariciresinol can attenuate mammary tumor growth and reduce blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats.

Lariciresinol

Lariciresinol

Purity: 99.84%
Catalog No. TN1853Cas No. 27003-73-2
Lariciresinol is an enterolignan precursor, it possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious diseases in humans. Dietary lariciresinol can attenuate mammary tumor growth and reduce blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats.
Pack SizePriceAvailabilityQuantity
1 mg$172In Stock
5 mg$433In Stock
10 mg$638In Stock
25 mg$987In Stock
50 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$439In Stock
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Purity:99.84%
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Product Introduction

Bioactivity
Description
Lariciresinol is an enterolignan precursor, it possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious diseases in humans. Dietary lariciresinol
In vitro
In this study, the antifungal properties and mode of action of Lariciresinol were investigated. Lariciresinol displays potent antifungal properties against several human pathogenic fungal strains without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of action of Lariciresinol, the membrane interactions of Lariciresinol were examined. Fluorescence analysis using the membrane probe 3,3'-diethylthio-dicarbocyanine iodide (DiSC(3)-5) and 1,6-diphenyl-1,3,5-hexatriene (DPH), as well as a flow cytometric analysis with propidium iodide (PI), a membrane-impermeable dye, indicated that Lariciresinol was associated with lipid bilayers and induced membrane permeabilization.
Chemical Properties
Molecular Weight360.4
FormulaC20H24O6
Cas No.27003-73-2
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/ml (152.61 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7747 mL13.8735 mL27.7469 mL138.7347 mL
5 mM0.5549 mL2.7747 mL5.5494 mL27.7469 mL
10 mM0.2775 mL1.3873 mL2.7747 mL13.8735 mL
20 mM0.1387 mL0.6937 mL1.3873 mL6.9367 mL
50 mM0.0555 mL0.2775 mL0.5549 mL2.7747 mL
100 mM0.0277 mL0.1387 mL0.2775 mL1.3873 mL

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