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LAS17

Name: LAS17
Brand: TargetMol
SKU: T39906
Price: 313 EUR
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39906Cas No. 2362527-67-9

LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth.

LAS17

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Purity: 97.06%

Catalog No. T39906Cas No. 2362527-67-9

Pack Size	Price	Availability	Quantity
2 mg	313 €	In Stock

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Purity:97.06%

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth.
In vitro	METHODS: To determine whether LAS17 (0-100 μM) inhibits GSTP1 activity, an in vitro activity assay was performed, monitoring the transfer of glutathione (GSH) to 1-bromo-2,4-dinitrobenzene (BDNB) spectrophotometrically. RESULTS:LAS17 inhibited GSTP1 activity in vitro in a concentration-dependent manner. [1] METHODS: 231MFP cells were treated with LAS17 (10 μM, 48 hours) and their serum-free cell viability was measured. RESULTS:LAS17 treatment reduced the level of phosphorylated S6 downstream of mTOR and S6 kinase in 231MFP breast cancer cells. [2]
In vivo	METHODS: LAS17 (20 mg/kg, intraperitoneal injection, once a day) was used to treat 231MFP tumor xenografted mice in immunodeficient mice and the tumor growth was observed. RESULTS:LAS17 significantly inhibited the growth of 231MFP breast tumor xenografts in immunodeficient mice, had no cytotoxicity, and had no effect on the body weight of mice. [2]

Chemical Properties

Molecular Weight	359.25
Formula	C₁₅H₂₀Cl₂N₄O₂
Cas No.	2362527-67-9
Smiles	N([C@@H](C(OC)=O)CC(C)C)(CCCC#C)C=1N=C(Cl)N=C(Cl)N1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL（222.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7836 mL	13.9179 mL	27.8358 mL	139.1788 mL
5 mM	0.5567 mL	2.7836 mL	5.5672 mL	27.8358 mL
10 mM	0.2784 mL	1.3918 mL	2.7836 mL	13.9179 mL
20 mM	0.1392 mL	0.6959 mL	1.3918 mL	6.9589 mL
50 mM	0.0557 mL	0.2784 mL	0.5567 mL	2.7836 mL
100 mM	0.0278 mL	0.1392 mL	0.2784 mL	1.3918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc