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LAS17
Catalog No. T39906Cas No. 2362527-67-9
LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth.
LAS17
Catalog No. T39906Cas No. 2362527-67-9
LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $330 | In Stock |
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Purity:97.06%
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Product Introduction
Bioactivity
Chemical Properties
| Description | LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth. |
| In vitro | METHODS: To determine whether LAS17 (0-100 μM) inhibits GSTP1 activity, an in vitro activity assay was performed, monitoring the transfer of glutathione (GSH) to 1-bromo-2,4-dinitrobenzene (BDNB) spectrophotometrically. RESULTS:LAS17 inhibited GSTP1 activity in vitro in a concentration-dependent manner. [1] METHODS: 231MFP cells were treated with LAS17 (10 μM, 48 hours) and their serum-free cell viability was measured. RESULTS:LAS17 treatment reduced the level of phosphorylated S6 downstream of mTOR and S6 kinase in 231MFP breast cancer cells. [2] |
| In vivo | METHODS: LAS17 (20 mg/kg, intraperitoneal injection, once a day) was used to treat 231MFP tumor xenografted mice in immunodeficient mice and the tumor growth was observed. RESULTS:LAS17 significantly inhibited the growth of 231MFP breast tumor xenografts in immunodeficient mice, had no cytotoxicity, and had no effect on the body weight of mice. [2] |
| Molecular Weight | 359.25 |
| Formula | C15H20Cl2N4O2 |
| Cas No. | 2362527-67-9 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL（222.69 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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