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LCS-1
🥰Excellent
Catalog No. T60386Cas No. 41931-13-9
Alias LCS1
LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells.
LCS-1
🥰Excellent
Catalog No. T60386Alias LCS1Cas No. 41931-13-9
LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $36 | In Stock | |
| 5 mg | $56 | In Stock | |
| 10 mg | $80 | In Stock | |
| 25 mg | $132 | In Stock | |
| 50 mg | $193 | In Stock | |
| 100 mg | $287 | In Stock | |
| 200 mg | $428 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells. |
| Targets&IC50 | ANBL6-BR (bortezomib-resistant) cells:4.6 μM, ANBL6-WT (bortezomib-sensitive) cells:2.5 μM, normal human bronchial epithelial cells:2.66 μM |
| In vitro | LCS-1 (1-10,000 nM, 24 hours) exhibits selective cytotoxicity in HCT116 cells against cells with the BLM gene and BLM-deficient cells. [1] LCS-1 exhibited inhibitory effects on adenocarcinoma cell lines (e.g., H23, H2347, HCC827, median IC50 of 0.20 μM), whereas the IC50 for normal human bronchial epithelial cells (NHBE) was 2.66 μM.[2] In multiple myeloma (MM) cells, LCS-1 (0, 1.25, 2 μM, 4 h) significantly inhibited SOD1 enzyme activity in a concentration-dependent manner, and LCS-1 (0, 1.25, 2.5, 5 μM, 48 h) dose-dependently reduced the survival of several MM cell lines, including MM.1R (dexamethasone-resistant), Dox40 (adriamycin-resistant), and LR5 (melphalan-resistant) cell lines. In ANBL6-WT (bortezomib-sensitive) and ANBL6-BR (bortezomib-resistant) cells, the IC50 of LCS-1 treatment for 48 hours was 2.5 μM and 4.6 μM, respectively.[3] |
| In vivo | In vivo experiments, LCS-1 (20 mg/kg, intraperitoneal injection every other day for 14 days) significantly inhibited the growth of multiple myeloma and prolonged the survival of MM.1S-carrying mice. [3] |
| Alias | LCS1 |
| Molecular Weight | 255.1 |
| Formula | C11H8Cl2N2O |
| Cas No. | 41931-13-9 |
| Smiles | O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(=C2)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (156.8 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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