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Lestaurtinib
🥰Excellent
Catalog No. T15738Cas No. 111358-88-4
Alias KT-5555, KT5555, KT 5555, CEP-701, CEP701, CEP 701
Lestaurtinib (CEP 701) is an orally available and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3, IC50: 0.9 nM), which inhibits FLT3 autophosphorylation in vitro.Lestaurtinib promotes the expression of c-MYC, inhibits the phosphorylation of RPTKs, and has high affinity for TrkA and JAK2. Lestaurtinib promotes c-MYC expression, inhibits phosphorylation of RPTKs, has a high affinity for TrkA and JAK2, induces apoptosis and cell growth arrest, and can be used to study leukemia.
Lestaurtinib
🥰Excellent
Purity: 99.17%
Catalog No. T15738Alias KT-5555, KT5555, KT 5555, CEP-701, CEP701, CEP 701Cas No. 111358-88-4
Lestaurtinib (CEP 701) is an orally available and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3, IC50: 0.9 nM), which inhibits FLT3 autophosphorylation in vitro.Lestaurtinib promotes the expression of c-MYC, inhibits the phosphorylation of RPTKs, and has high affinity for TrkA and JAK2. Lestaurtinib promotes c-MYC expression, inhibits phosphorylation of RPTKs, has a high affinity for TrkA and JAK2, induces apoptosis and cell growth arrest, and can be used to study leukemia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $499 | In Stock |
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Purity:99.17%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lestaurtinib (CEP 701) is an orally available and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3, IC50: 0.9 nM), which inhibits FLT3 autophosphorylation in vitro.Lestaurtinib promotes the expression of c-MYC, inhibits the phosphorylation of RPTKs, and has high affinity for TrkA and JAK2. Lestaurtinib promotes c-MYC expression, inhibits phosphorylation of RPTKs, has a high affinity for TrkA and JAK2, induces apoptosis and cell growth arrest, and can be used to study leukemia. |
| Targets&IC50 | TrkA:25 nM, JAK2:0.9 nM, FLT3:3 nM |
| In vitro | METHODS: Cells were treated with different concentrations of Lestaurtinib (0.5 μM and 4.0 μM) and cell viability was assessed using PrestoBlue at different time points (0, 24, 48, and 72 hours) by measuring the fluorescence intensity to evaluate cell proliferation. RESULTS: Lestaurtinib demonstrated good proliferative inhibitory activity against the KMH2, CAL62, and THJ-21T cell lines[1]. |
| In vivo | METHODS: Lestaurtinib (20 mg/kg; subcutaneous injection; twice daily from Monday to Friday and once daily on Saturday and Sunday; for 3 weeks) was administered to four-week-old athymic nude mice (SY5Y-TrkB xenograft model) to evaluate its therapeutic effect in a preclinical neuroblastoma model. RESULTS: Lestaurtinib significantly slowed the growth of SY5Y-TrkB xenografts [3]. |
| Alias | KT-5555, KT5555, KT 5555, CEP-701, CEP701, CEP 701 |
| Molecular Weight | 439.46 |
| Formula | C26H21N3O4 |
| Cas No. | 111358-88-4 |
| Smiles | C[C@]12N3C=4C=5N(C=6C(C5C7=C(C4C=8C3=CC=CC8)CNC7=O)=CC=CC6)[C@](O1)(C[C@@]2(CO)O)[H] |
| Relative Density. | 1.7g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (91.02 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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