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Levomepromazine
🥰Excellent
Catalog No. T15743Cas No. 60-99-1
Alias Methotrimeprazine
Levomepromazine (Methotrimeprazine) is an orally active aliphatic phenothiazine antipsychotic compound and a Ca2+ release inducer, exhibiting antiviral, anti-inflammatory, neuroprotective, analgesic, and anti-nociceptive activities. Levomepromazine inhibits dopaminergic, cholinergic, serotoninergic, and histaminergic receptors, and is used for research in neurodegenerative diseases.
Levomepromazine
🥰Excellent
Purity: 99.15%
Catalog No. T15743Alias MethotrimeprazineCas No. 60-99-1
Levomepromazine (Methotrimeprazine) is an orally active aliphatic phenothiazine antipsychotic compound and a Ca2+ release inducer, exhibiting antiviral, anti-inflammatory, neuroprotective, analgesic, and anti-nociceptive activities. Levomepromazine inhibits dopaminergic, cholinergic, serotoninergic, and histaminergic receptors, and is used for research in neurodegenerative diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $75 | In Stock |
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Purity:99.15%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Levomepromazine (Methotrimeprazine) is an orally active aliphatic phenothiazine antipsychotic compound and a Ca2+ release inducer, exhibiting antiviral, anti-inflammatory, neuroprotective, analgesic, and anti-nociceptive activities. Levomepromazine inhibits dopaminergic, cholinergic, serotoninergic, and histaminergic receptors, and is used for research in neurodegenerative diseases. |
| In vitro | Levomepromazine(0.01-200 μM,72h) increased the CYP3A4 activity of HU1832 to 152% at 2.5 μM. [1] Levomepromazine (10 μM, 24 h) reduced Japanese encephalitis virus (JEV) -induced Neuro2a cell death, decreased JEV RNA levels and viral titers, and significantly inhibited JEV protein translation/replication complex formation and ROS production. Levomepromazine (10 μM, 24 h) reduces inflammation in microglia by inducing autophagy. [2] |
| In vivo | Levomepromazine (5-20 mg/kg; Intraperitoneal injection) has analgesic, sedative and anti-injurious effects in mice [4]. |
| Alias | Methotrimeprazine |
| Molecular Weight | 328.47 |
| Formula | C19H24N2OS |
| Cas No. | 60-99-1 |
| Smiles | C([C@@H](CN(C)C)C)N1C=2C(SC=3C1=CC=CC3)=CC=C(OC)C2 |
| Relative Density. | 1.0897 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (91.33 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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