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Lirentelimab
Catalog No. T76869Cas No. 2283348-97-8
Alias Antolimab, Anti-Siglec-8 Reference Antibody, AK002, AK 002
Lirentelimab (AK002) is a humanized anti-sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) antibody that induces apoptosis of IL-5-activated eosinophils and inhibits IL-5-mediated mast cell activation, and is used in the study of refractory inert systemic mastocytosis and allergic conjunctivitis.
Lirentelimab
Lirentelimab
Catalog No. T76869Alias Antolimab, Anti-Siglec-8 Reference Antibody, AK002, AK 002Cas No. 2283348-97-8
Lirentelimab (AK002) is a humanized anti-sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) antibody that induces apoptosis of IL-5-activated eosinophils and inhibits IL-5-mediated mast cell activation, and is used in the study of refractory inert systemic mastocytosis and allergic conjunctivitis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $197 | In Stock | |
| 5 mg | $516 | In Stock | |
| 10 mg | $828 | In Stock | |
| 25 mg | $1,230 | In Stock | |
| 50 mg | $1,650 | In Stock |
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Concentration:6.78 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lirentelimab (AK002) is a humanized anti-sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) antibody that induces apoptosis of IL-5-activated eosinophils and inhibits IL-5-mediated mast cell activation, and is used in the study of refractory inert systemic mastocytosis and allergic conjunctivitis. |
| Targets&IC50 | SIGLEC8:464 pM (affinity) |
| In vitro | The antigen-binding fragment of Lirentelimab binds with an affinity of 464 pM to the extracellular structural domain of recombinant SIGLEC8. Lirentelimab exhibits a high affinity for in vitro-expressed SIGLEC8 as well as SIGLEC8 expressed on eosinophils and via the Fc region on NK cells. At a concentration of 1 µg/mL, Lirentelimab selectively binds to eosinophils in human peripheral blood as well as eosinophils and mast cells in human lung tissue. In addition, Lirentelimab induced apoptosis in IL-5-activated eosinophils when acted at concentrations ranging from 0.0001 to 100 μg/mL for 30 minutes. In peripheral blood leukocyte samples from healthy donors, Lirentelimab had a half-maximal effect concentration of 1.9 ng/mL on eosinophils and elicited an antibody-dependent cytotoxic response.Lirentelimab also reduced the number of eosinophils in isolated human tissues. [1] |
| In vivo | Lirentelimab significantly inhibited IgE-mediated mast cell activation after a single intravenous injection at a dose of 100 μg in a mouse model of systemic allergic reaction. [1] |
| Alias | Antolimab, Anti-Siglec-8 Reference Antibody, AK002, AK 002 |
| Cas No. | 2283348-97-8 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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