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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $36 | In Stock | |
5 mg | $88 | In Stock | |
10 mg | $148 | In Stock | |
25 mg | $322 | In Stock | |
50 mg | $465 | In Stock | |
100 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9). |
Targets&IC50 | BRD9:(kd)99 nM |
In vitro | LP99 (0.8 μM) disrupts BRD9 interactions with chromatin. The addition of LP99 decreased BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose-dependent manner, with cellular IC50 values in the low micromolar range for both histone. LP99 inhibits IL-6 secretion from THP-1 cells in a dose-dependent manner. Cytotoxicity tests in U2OS cells for 24 and 72 hours display the inhibitor to be non-toxic at concentrations of <33 μM . |
Molecular Weight | 516.05 |
Formula | C26H30ClN3O4S |
Cas No. | 1808951-93-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (43.6 mM) ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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