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LSD1-IN-36
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Catalog No. T201218
LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.
LSD1-IN-36
😃Good
Catalog No. T201218
LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.
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| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity. |
| Targets&IC50 | LSD1:0.8 nM |
| In vitro | LSD1-IN-36 (compound 10e) exhibits significant inhibitory effects in various human tumor cell lines, showing strong activity against HCT116, MCF-7, A549, and MDA-MB-231 cells with IC50 values of 0.1 μM, 0.1 μM, 0.3 μM, and 0.8 μM, respectively. At concentrations ranging from 0.125 to 0.5 μM over 72 hours, LSD1-IN-36 significantly inhibits clonal formation in HCT116 cells, induces apoptosis, arrests the cell cycle, and increases the expression of H3K9me2, H3K9me1, H3K4me2, and H3K4me1 in HCT116 cells. |
| In vivo | Administered intraperitoneally at a dose of 60 mg/kg daily for three weeks, LSD1-IN-36 (compound 10e) demonstrated a significant tumor suppression rate in vivo. |
| Molecular Weight | 459.52 |
| Formula | C22H25N3O6S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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