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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $155 | In Stock | |
25 mg | $262 | In Stock | |
50 mg | $389 | In Stock | |
100 mg | $573 | In Stock | |
500 mg | $1,190 | In Stock | |
1 mL x 10 mM (in DMSO) | $116 | In Stock |
Description | M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.M1002 alters the Tyr2 conformation of the HIF-281alpha PAS-B structural domain and acts synergistically with inhibitors of the prolyl hydroxylase structural domain (PHD). |
In vitro | M1002 (10 μM; 24 h; 786-O cells) enhances the expression of HIF-2 target genes with great efficacy compared with the control. M1002 treatment (5 μM) shows synergy with prolyl hydroxylase domain (PHD) inhibitors.[1] |
Molecular Weight | 394.29 |
Formula | C15H8F6N2O2S |
Cas No. | 823830-85-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (25.36 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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