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Mavacoxib
🥰Excellent
Catalog No. T7670Cas No. 170569-88-7
Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
Mavacoxib
🥰Excellent
Purity: 99.36%
Catalog No. T7670Cas No. 170569-88-7
Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $47 | In Stock | |
| 10 mg | $76 | In Stock | |
| 25 mg | $147 | In Stock | |
| 50 mg | $228 | In Stock | |
| 100 mg | $343 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $52 | In Stock |
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Purity:99.36%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity. |
| In vitro | Mavacoxib is cytotoxic to a panel of human and canine osteosarcoma, mammary and bladder carcinoma cancer cell lines;?that it can induce apoptosis and inhibit the migration of these cells.?Mavacoxib can exert these effects independently of elevated COX-2 expression[1].Mavacoxib has a direct cell killing effect on cancer cells, increases apoptosis in cancer cells in a manner that may be independent of caspase activity, and has an inhibitory effect on cell migration.?Importantly, that cancer stem cells derived from osteosarcoma cell lines are sensitive to the cytotoxic effect of mavacoxib[2] |
| Molecular Weight | 385.34 |
| Formula | C16H11F4N3O2S |
| Cas No. | 170569-88-7 |
| Smiles | NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F |
| Relative Density. | 1.51 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (58.39 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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