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Mavacoxib

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Purity:99.36%

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COA HPLC HNMR

Mavacoxib

Catalog No. T7670Cas No. 170569-88-7

Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.

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Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$47	In Stock
10 mg	$76	In Stock
25 mg	$147	In Stock
50 mg	$228	In Stock
100 mg	$343	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Questions

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Product Introduction

Bioactivity

Description

Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.

In vitro

Mavacoxib is cytotoxic to a panel of human and canine osteosarcoma, mammary and bladder carcinoma cancer cell lines;?that it can induce apoptosis and inhibit the migration of these cells.?Mavacoxib can exert these effects independently of elevated COX-2 expression[1].Mavacoxib has a direct cell killing effect on cancer cells, increases apoptosis in cancer cells in a manner that may be independent of caspase activity, and has an inhibitory effect on cell migration.?Importantly, that cancer stem cells derived from osteosarcoma cell lines are sensitive to the cytotoxic effect of mavacoxib[2]

Chemical Properties

Molecular Weight	385.34
Formula	C16H11F4N3O2S
Cas No.	170569-88-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (58.39 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5951 mL	12.9756 mL	25.9511 mL	129.7555 mL
5 mM	0.5190 mL	2.5951 mL	5.1902 mL	25.9511 mL
10 mM	0.2595 mL	1.2976 mL	2.5951 mL	12.9756 mL
20 mM	0.1298 mL	0.6488 mL	1.2976 mL	6.4878 mL
50 mM	0.0519 mL	0.2595 mL	0.5190 mL	2.5951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc