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Mavorixafor trihydrochloride
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Catalog No. T10296Cas No. 2309699-17-8
Alias AMD-070 trihydrochloride
Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
Mavorixafor trihydrochloride
😃Good
Catalog No. T10296Alias AMD-070 trihydrochlorideCas No. 2309699-17-8
Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $87 | 5 days | |
| 25 mg | $652 | 1-2 weeks | |
| 50 mg | $847 | 1-2 weeks | |
| 100 mg | $1,390 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM). |
| Targets&IC50 | [125I]-SDF-CXCR4:13 nM, HIV-1 (NL4.3 strain):3 nM (IC90, in MT-4 cells), HIV-1 (NL4.3 strain):1 nM (in MT-4 cells), HIV-1:26 nM (IC90, in PBMCs), HIV-1 (NL4.3 strain):9 nM (in PBMCs) |
| In vitro | Mavorixafor (AMD-070) shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [1]. Mavorixafor (6.6 μM) significantly suppresses the anchorage-dependent growth, the migration and matrigel invasion of the B88-SDF-1 cells [2]. |
| In vivo | Mavorixafor, at a dosage of 2 mg/kg administered orally, substantially decreases the count of metastatic lung nodules in mice while concurrently reducing the expression of human Alu DNA, all without causing loss in body weight [2]. |
| Alias | AMD-070 trihydrochloride |
| Molecular Weight | 458.86 |
| Formula | C21H30Cl3N5 |
| Cas No. | 2309699-17-8 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 6 mg/mL (13.08 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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