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MC3343, a DNMT inhibitor with IC50 values of 5.7 μM for DNMT1 and 1.7 μM for DNMT3a, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation by specifically re-expressing genes that regulate this physiological process, and is able to show synergistic effects in combination with adriamycin and cisplatin (CDDP).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | In Stock | |
50 mg | Inquiry | In Stock |
Description | MC3343, a DNMT inhibitor with IC50 values of 5.7 μM for DNMT1 and 1.7 μM for DNMT3a, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation by specifically re-expressing genes that regulate this physiological process, and is able to show synergistic effects in combination with adriamycin and cisplatin (CDDP). |
Alias | MC 3343 |
Molecular Weight | 461.52 |
Formula | C27H23N7O |
Cas No. | 1535187-91-7 |
Smiles | O=C(NC=1C=CC=C(C1)NC2=NC(=NC(=C2)C)N)C=3C=CC=C(C3)NC=4C=CN=C5C=CC=CC54 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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