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MG-115
Catalog No. T21617Cas No. 133407-86-0
Alias Z-LL-Nva-CHO
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].
MG-115
Catalog No. T21617Alias Z-LL-Nva-CHOCas No. 133407-86-0
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $179 | In Stock | |
| 25 mg | $328 | In Stock | |
| 50 mg | $488 | In Stock | |
| 100 mg | $713 | In Stock | |
| 200 mg | $987 | In Stock |
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Purity:97.12%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3]. |
| In vitro | MG-115, at concentrations ranging from 0.1 to 10 μM over 24 hours, not only diminishes the viability of HepG2 cells in a dose-dependent manner but also enhances the reporter gene expression driven by CWK 18 DNA condensates. Cell viability assays further confirm that MG-115's exposure leads to a dose-dependent decrease in cell viability, quantitatively inhibiting proteasomal activity with an IC 50 value of 2 μM in HepG2 cells. |
| Alias | Z-LL-Nva-CHO |
| Molecular Weight | 461.59 |
| Formula | C25H39N3O5 |
| Cas No. | 133407-86-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (97.5 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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