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MK-0773

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Purity:99.63%

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COA HPLC LCMS HNMR

MK-0773

Catalog No. T16090Cas No. 606101-58-0

MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.

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Pack Size	Price	Availability
1 mg	$78	In Stock
5 mg	$188	In Stock
10 mg	$289	In Stock
1 mL x 10 mM (in DMSO)	$196	In Stock

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Product Introduction

Bioactivity

Description	MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.
In vitro	The affinity of MK-0773 for AR across species can be evaluated using COS cells transfected with AR, with respective IC50 values as follows: rat, 0.50 nM; dog, 0.55 nM; rhesus, 0.45 nM; human, 0.65 nM[1].
In vivo	Treatment of OVX rats with MK-0773 (5 mg/kg, 25 mg/kg), 2-FPA, TFM-4AS-1, and DHT for 24 days resulted in a decrease in total cholesterol and high-density lipoprotein by 25-37%[1].
Alias	PF-05314882

Chemical Properties

Molecular Weight	479.59
Formula	C27H34FN5O2
Cas No.	606101-58-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (41.70 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0851 mL	10.4256 mL	20.8511 mL	104.2557 mL
5 mM	0.4170 mL	2.0851 mL	4.1702 mL	20.8511 mL
10 mM	0.2085 mL	1.0426 mL	2.0851 mL	10.4256 mL
20 mM	0.1043 mL	0.5213 mL	1.0426 mL	5.2128 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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