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MK-0773

TargetMol
Catalog No. T16090Cas No. 606101-58-0
Alias PF-05314882

MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.

MK-0773

MK-0773

TargetMol
Purity: 99.63%
Catalog No. T16090Alias PF-05314882Cas No. 606101-58-0
MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.
Pack SizePriceAvailabilityQuantity
1 mg$78In Stock
5 mg$188In Stock
10 mg$289In Stock
1 mL x 10 mM (in DMSO)$196In Stock
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Purity:99.63%
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Product Introduction

Bioactivity
Description
MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.
Targets&IC50
Androgen receptor:6.6 nM
In vitro
The affinity of MK-0773 for AR across species can be evaluated using COS cells transfected with AR, with respective IC50 values as follows: rat, 0.50 nM; dog, 0.55 nM; rhesus, 0.45 nM; human, 0.65 nM[1].
In vivo
Treatment of OVX rats with MK-0773 (5 mg/kg, 25 mg/kg), 2-FPA, TFM-4AS-1, and DHT for 24 days resulted in a decrease in total cholesterol and high-density lipoprotein by 25-37%[1].
AliasPF-05314882
Chemical Properties
Molecular Weight479.59
FormulaC27H34FN5O2
Cas No.606101-58-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (41.70 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0851 mL10.4256 mL20.8511 mL104.2557 mL
5 mM0.4170 mL2.0851 mL4.1702 mL20.8511 mL
10 mM0.2085 mL1.0426 mL2.0851 mL10.4256 mL
20 mM0.1043 mL0.5213 mL1.0426 mL5.2128 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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