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ML329
Catalog No. T4028Cas No. 19992-50-8
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
ML329
Catalog No. T4028Cas No. 19992-50-8
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 2 mg | $67 | In Stock | |
| 5 mg | $117 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $447 | In Stock | |
| 50 mg | $659 | In Stock | |
| 100 mg | $939 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $121 | In Stock |
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CitedSelect Batch
Purity:99.07%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity. |
| Targets&IC50 | MITF:1.2 μM. |
| In vitro | ML329 effectively reduces the expression of various micropthalmia-associated transcription factor (MITF) target genes and impedes the growth of several cell lines reliant on MITF for proliferation. This compound potentially interacts with MITF or its regulatory elements directly or indirectly. Given MITF's critical role in regulating the cell cycle and pigmentation, ML329's interference with MITF presents a promising approach to elucidate MITF's specific functions in melanoma and to assess the inhibition of MITF's activity as a viable melanoma treatment strategy. Notably, ML329 selectively targets MITF-dependent cells and primary melanocytes without affecting the viability of A375 cells. It also diminishes the expression of key MITF target genes involved in pigmentation and cell cycle regulation, such as CDK2. Thus, ML329 serves as an invaluable research tool to explore MITF's contribution to the development of melanocyte lineage and the progression of melanoma. |
| Molecular Weight | 328.34 |
| Formula | C16H12N2O4S |
| Cas No. | 19992-50-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (30.46 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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