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ML353

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Purity:99.82%

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COA LCMS HPLC HNMR

ML353

Catalog No. T67917

ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or pharmacological blockade of SAM in vivo.

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Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$106	In Stock
10 mg	$173	In Stock
25 mg	$293	In Stock
50 mg	$397	In Stock
100 mg	$581	In Stock
500 mg	$1,150	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Product Introduction

Bioactivity

Description	ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or pharmacological blockade of SAM in vivo.
In vitro	ML353 is a highly soluble compound with a solubility of 16.9 µM or 6.0 µg/mL (pH=7.4) in PBS. ML353 demonstrates excellent stability in PBS buffer.[1]
Alias	VU0478006

Chemical Properties

Molecular Weight	306.33
Formula	C19H15FN2O
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (81.61 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2645 mL	16.3223 mL	32.6445 mL	163.2227 mL
5 mM	0.6529 mL	3.2645 mL	6.5289 mL	32.6445 mL
10 mM	0.3264 mL	1.6322 mL	3.2645 mL	16.3223 mL
20 mM	0.1632 mL	0.8161 mL	1.6322 mL	8.1611 mL
50 mM	0.0653 mL	0.3264 mL	0.6529 mL	3.2645 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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