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Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
200 mg | 28 € | In Stock | |
1 mL x 10 mM (in DMSO) | 28 € | In Stock |
Description | Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound. |
In vivo | Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart[1]. |
Alias | SIN-10, Morsydomine, Corvaton |
Molecular Weight | 242.23 |
Formula | C9H14N4O4 |
Cas No. | 25717-80-0 |
Smiles | [N-](C(OCC)=O)C1=C[N+](=NO1)N2CCOCC2 |
Relative Density. | 1.3186 g/cm3 (Estimated) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (185.8 mM) H2O: 9 mg/mL (37.15 mM) Ethanol: 21 mg/mL (86.7 mM) | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
Ethanol/DMSO
DMSO
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