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Molsidomine

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Purity:100%

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COA LCMS HNMR

Molsidomine

Catalog No. T0109Cas No. 25717-80-0

Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

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Pack Size	Price	Availability	Quantity
200 mg	$32	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
In vivo	Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart[1].
Alias	Morsydomine, SIN-10, Corvaton

Chemical Properties

Molecular Weight	242.23
Formula	C9H14N4O4
Cas No.	25717-80-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (185.8 mM)

H2O: 9 mg/mL (37.15 mM)

Ethanol: 21 mg/mL (86.7 mM)

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1283 mL	20.6415 mL	41.2831 mL	206.4154 mL
5 mM	0.8257 mL	4.1283 mL	8.2566 mL	41.2831 mL
10 mM	0.4128 mL	2.0642 mL	4.1283 mL	20.6415 mL
20 mM	0.2064 mL	1.0321 mL	2.0642 mL	10.3208 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0826 mL	0.4128 mL	0.8257 mL	4.1283 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0413 mL	0.2064 mL	0.4128 mL	2.0642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc