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MRTX0902

Catalog No. T9755 CAS 2654743-22-1

Synonyms: UNII-CRG69FR93G

MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MRTX0902, CAS 2654743-22-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 87.00
5 mg	In stock	$ 213.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 1,060.00
100 mg	In stock	$ 1,730.00

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Purity: 98.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.
In vitro	In the MIA PaCa-2 xenograft model of mice, MRTX0902 (25 and 50 mg/kg; p.o.) shows anti-tumor effects and reduces tumor growth by 41% and 53%, respectively[1].

Synonyms	UNII-CRG69FR93G
Molecular Weight	388.47
Formula	C22H24N6O
CAS No.	2654743-22-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (25.7 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Ketcham JM, et al. Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. J Med Chem. 2022 Jul 28;65(14):9678-9690.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Immunology/Inflammation Compound Library Anti-Obesity Compound Library Anti-Prostate Cancer Compound Library Anti-Colorectal Cancer Compound Library

Related Products

Related compounds with same targets

Encorafenib ARS-853 Cyclorasin 9A5 Indirubin Rineterkib Dabrafenib Regorafenib monohydrate RAF265

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MRTX0902 2654743-22-1 MAPK Raf UNII-CRG69FR93G MRTX 0902 MRTX-0902 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.