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N-Oleoyl glycine

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Purity:99.92%

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COA HPLC HNMR

N-Oleoyl glycine

Catalog No. T13803Cas No. 2601-90-3

N-Oleoyl glycine, a lipoamino acid, was able to promote 3T3-L1 adipogenesis through the activation of CB1 receptor and the enhancement of insulin-mediated Akt signaling pathway.

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$64	In Stock
25 mg	$98	In Stock
50 mg	$153	In Stock
100 mg	$229	In Stock
200 mg	$342	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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Product Introduction

Bioactivity

Description

N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte

In vitro

N-Oleoyl glycine stimulated lipid accumulation and significantly increased adipogenic genes (PPARγ and aP2), in a dose- and time-dependent manner.?Additionally, N-Oleoyl glycine markedly increased the mRNA expression of CB1 receptor and the inhibition of CB1R by its antagonist SR141716 abolished the promotive effects of N-Oleoyl glycine on lipid accumulation and the protein expression of PPARγ and aP2.?Furthermore, N-Oleoyl glycine increased the ratio of p-Akt/Akt and p-FoxO1/FoxO1, which could be reversed by SR141716.?Moreover, N-Oleoyl glycine-induced enhancement of adipogenesis, activation of insulin-mediated Akt signaling pathway and inactivation of FoxO1 were effectively blocked by Wortmannin, a specific PI3K/Akt inhibitor, indicating the essential role of Akt signaling pathway in the process of N-Oleoyl glycine-stimulated 3T3-L1 adipogenesis[1].

Chemical Properties

Molecular Weight	339.51
Formula	C20H37NO3
Cas No.	2601-90-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (235.63 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9454 mL	14.7271 mL	29.4542 mL	147.2711 mL
5 mM	0.5891 mL	2.9454 mL	5.8908 mL	29.4542 mL
10 mM	0.2945 mL	1.4727 mL	2.9454 mL	14.7271 mL
20 mM	0.1473 mL	0.7364 mL	1.4727 mL	7.3636 mL
50 mM	0.0589 mL	0.2945 mL	0.5891 mL	2.9454 mL
100 mM	0.0295 mL	0.1473 mL	0.2945 mL	1.4727 mL

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